IS NEMBUTAL A BARBITURATE NO FURTHER A MYSTERY

Barbiturates can induce hepatic microsomal enzymes resulting in elevated metabolism and decreased anticoagulant reaction of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon); patients stabilized on anticoagulant therapy may involve dosage changes if barbiturates are additional to or withdrawn from their dosage regimenp